Reader in Cancer Risk Prediction
Tel. +44 (0)1223 748630
Dr Antoniou studied at the London School of Economics and Political Science and the University of Cambridge before gaining his PhD in Genetic Epidemiology at Cambridge in 2001. In 2013 he was appointed a Reader in Cancer Risk Prediction. He is currently a Cancer Research UK Senior Cancer Research Fellow and leads a research group within the Department of Public Health and Primary Care.
Dr Antoniou’s main research interests are the development and application of statistical modelling techniques to the inherited susceptibility of cancer, in particular breast, ovarian and other common cancers.
His research group focuses on two broad areas:
- The development and evaluation of risk prediction models for familial breast, ovarian, prostate and other cancers with a familial component.
- The identification and characterisation of modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers through analysis of large scale genome-wide and candidate gene association studies.
Specific ongoing projects include: the development of the BOADICEA risk prediction algorithm which can be used for predicting the risk of developing breast or ovarian cancer and the likelihood of carrying BRCA1 and BRCA2 mutations; investigation of candidate polymorphisms as genetic modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers using data from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA); a genome-wide study of genetic modifiers of risk for BRCA1 mutation carries (BRCA1 GWAS).
Since 2010 Dr Antoniou has lectured for part of the MPhil in Epidemiology and currently mentors for PhD and MPhil students.
Couch FC, Kuchenbaecker, et al… Antoniou AC (2016). Identification of four novel susceptibility loci for estrogen receptor negative breast cancer. Nat Commun Apr 27;7:11375 PubMed ID: 27117709
Lee, A., et al… Antoniou AC (2016) Incorporating Truncating Variants in PALB2, CHEK2 and ATM into the BOADICEA Breast Cancer Risk Model. Genetics In Medicine net Med. 2016 Apr 14. 2016 Dec;18(12):1190-1198. Pubmed ID: 27464310
Dunning A., et al … Antoniou AC*, Easton DF*, Edwards SL*(2016) Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170, Nature Genetics 48(4):374-86 PubMed ID: 26928228 *Joint senior author
Silvestri V, et al… Antoniou AC*, Ottini L* (2016) Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res. 2016 Feb 9;18(1):15 PubMed ID: 26857456 *Joint senior author
Ramus SJ, et al … (2015) Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. J Natl Cancer Inst. 2015 Aug 27;107(11) PubMed ID: 26315354
Jervis, S.,et al… Antoniou AC (2015) A Risk Prediction Algorithm for Ovarian Cancer Incorporating BRCA1, BRCA2, Common Alleles and Other Familial Effects. J Med Genet 52: 465-75 PubMed ID: 26025000
Easton, D.F., et al… (2015) Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk. N Engl J Med Jun 4;372(23):2243-57 PubMed ID: 26014596
Rebbeck, T.R., et al… (2015) Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. JAMA 313, 1347-1361 PubMed ID: 25849179
Kuchenbaecker, K.B., et al… Antoniou, AC*, and Chenevix-Trench, G.* (2015) Identification of six new susceptibility loci for invasive epithelial ovarian cancer.Nature genetics 47, 164-171. PubMed ID: 25581431 *Joint senior author
Kuchenbaecker, K., et al…. Antoniou AC, (2014) Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers.Breast Cancer Research 16, 3416. PubMed ID: 25919761
Antoniou, A.C., et al… (2014) Breast-cancer risk in families with mutations in PALB2. N Engl J Med 371:497-506. PubMed ID: 25337756
Lee AJ, et al … Antoniou AC (2013) BOADICEA breast cancer risk prediction model: updates to cancer incidences, tumour pathology and web interface.Br J Cancer 110(2):535-45. PubMed ID: 24346285
Couch FJ, et al … Antoniou AC (2013) Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk. PLOS Genetics (Mar;9(3):e1003212.) PubMed ID: 23544013
Barnes DR, et al … Antoniou AC (2012) Evaluation of Association Methods for Analysing Modifiers of Disease Risk in Carriers of High-Risk Mutations.Genet Epidemiol 36:274-91 PubMed ID: 22714938
Mulligan AM, et al … Antoniou AC (2011) Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.Br Cancer Res 13(6):R11 PubMed ID: 22053997
Loveday C, et al … (2011) RAD51D is an ovarian cancer predisposition gene. Nat Genet 43:879-82 PubMed ID: 21822267
Mcinnis RJ, et al … (2011) A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact.Genet Epidemiol 35:549-56 PubMed ID: 21769933
Antoniou AC, et al … (2010) Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction.Cancer Res 70:9742-54 PubMed ID: 21118973
Antoniou AC, et al … (2010) A locus on 19p13 locus modifies risk of breast cancer for BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.Nat Genet 42:174-91 PubMed ID: 20852631
Mavaddat N, et al … (2010) Incorporating tumour pathology information into breast cancer risk prediction algorithms.Breast Cancer Res 18;12(3):R28. PubMed ID: 20482762
Antoniou AC, et al … (2008) The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.Br J Cancer 98:1457-66. PubMed ID: 18349832