The Centre for Cancer Genetic Epidemiology carries out research into inherited predisposition to cancer, with a particular emphasis on common cancers. The unit’s aims are: to identify cancer predisposition genes; to define their frequencies, associated risks and their interaction with environmental risk factors and to evaluate strategies for avoiding inherited risks of cancer. It is also actively involved in developing statistical methodology.
A small number of men and women have inherited faulty genes which means that they are at an increased risk of developing certain cancers. Two of these genes are called BRCA1 and BRCA2.
The SEARCH Study is an ongoing study of genetic susceptibility to the common cancers, the main purpose of which is to determine how normal, common genetic variation affects cancer risk. The study hopes to achieve this by collecting a blood sample and information on family history and lifestyle from men and women in East Anglia who have been diagnosed with specific cancers.
A Genetic Study of Quantitative Phenotypes Related to Breast Cancer. This research is one of many studies going on in Cambridge into breast cancer.
Laboratory analysis takes place at Strangeways Laboratory. This includes extraction of DNA, RNA, plasma from blood samples as well as SNP genotyping.
The major goal of this project is to examine the genetic basis of telomere shortening and its effect on risk of breast, colorectal and prostate cancer.