The Admixture Maximum Likelihood test is a method for carrying out an omnibus test of association between multiple single nucleotide polymorphisms and disease in case control studies (Tyrer J, Pharoah PDP, Easton DF. The admixture maximum likelihood test: A novel experiment-wise test of association between disease and multiple SNPs. Genet. Epidemiol. 2006;30(7):636-43). An example of the use of the methodology is published in PLoS Genet. 2007 Mar 16;3(3):e42. Epub 2007 Feb 2. The method has been adapted for survival time analysis. The programme is implemented as a Windows GUI and also a 64 bit Linux command line executable. The download includes instructions on its use with some example data files.
Click here for Windows AML zip file
Click here for Linux (64-bit) AML tar file
For further information on AML please contact Jonathan Tyrer.