The core components of the study include the following:

• baseline epidemiological questionnaire; recruit self-reports lifestyle, screening and medical information
• blood samples; for researching genotypes and other blood factors relating to risk and cancer
• pedigree; for family history information obtained from the clinics 
• cancer pathology and clinical details/treatments; obtained from medical records
• tumour tissue
• follow up, after recruitment, to include-
  • questionnaires & blood at 2, 5 and 10 years after recruitment
  • Additional intervening blood samples for eligible participants in the Early Detection program
  • NHS Digital reports for events, including those after 10 years