Selected publications below.
Carver T, Hartley S, Lee A, Cunningham AP, Archer S, Babb de Villiers C, Roberts J, Ruston R, Walter FM, Tischkowitz M, Easton DF, Antoniou AC (2021) CanRisk Tool-A Web Interface for the Prediction of Breast and Ovarian Cancer Risk and the Likelihood of Carrying Genetic Pathogenic Variants Cancer Epidemiol Biomarkers Prev. 2021 PMID 33335023
Ho WK, et al (2021) European polygenic risk score for prediction of breast cancer shows similar performance in Asian women Nat Commun.PMID: 32737321
Yang X, et al … Antoniou AC, Tischkowitz M. (2020) Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families J Clin Oncol. PMID 31841383
Nyberg T, et al … Antoniou AC. (2020) Prostate Cancer Risks for Male BRCA1 and BRCA2 Mutation Carriers: A Prospective Cohort Study Eur Urol. PMID 31495749
Lee A, et al … Easton DF, Antoniou AC. (2019) BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors Genet Med. PMID 30643217
Nyberg T, et al … Antoniou AC. (2018) Homeobox B13 G84E Mutation and Prostate Cancer Risk Eur Urol PMID 30527799
Yang X, et al … Antoniou AC (2018) Evaluation of polygenic risk scores for ovarian cancer risk prediction in a prospective cohort study J Med Genet. 55(8):546-554 PMID 29730597
Kuchenbaecker KB, et al … (2017) Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers JAMA PMID 28632866
Phelan CM, et al … Pharoah PDP. (2017) Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer Nat Genet PMID 28346442
Milne RL, et al … (2017) Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer Nat Genet PMID 29058716
Kuchenbaecker KB, et al … Antoniou AC. (2017) Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers J Natl Cancer Inst PMID 28376175
Couch FC, Kuchenbaecker, et al… Antoniou AC (2016). Identification of four novel susceptibility loci for estrogen receptor negative breast cancer. Nat Commun Apr 27;7:11375 PMID 27117709
Lee, A., et al… (2016) Incorporating Truncating Variants in PALB2, CHEK2 and ATM into the BOADICEA Breast Cancer Risk Model. Genetics In Medicine net Med. 2016 Apr 14. PMID27464310
Dunning A., et al … Antoniou AC*, Easton DF*, Edwards SL*(2016) Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170, Nature Genetics 48(4):374-86 PMID26928228 *Joint senior author
Silvestri V, et al… Antoniou AC*, Ottini L* (2016) Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res. 2016 Feb 9;18(1):15 PMID 26857456 *Joint senior author
Mavaddat N, et al… (2015) Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst. Apr 8;107(5) PMID 25855707
Ramus SJ, et al … (2015) Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. J Natl Cancer Inst. 2015 Aug 27;107(11) PMID 26315354
Michailidou K, et al…Easton DF (2015) Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat Genet. 2015;47(4):373-80. PMID 25751625
Jervis, S.,et al… Antoniou AC (2015) A Risk Prediction Algorithm for Ovarian Cancer Incorporating BRCA1, BRCA2, Common Alleles and Other Familial Effects. J Med Genet 52: 465-75 PMID 26025000
Easton, D.F., et al… (2015) Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk. N Engl J Med Jun 4;372(23):2243-57 PMID 26014596
Rebbeck, T.R., et al… (2015) Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. JAMA 313, 1347-1361 PubMed ID 25849179
Kuchenbaecker, K.B., et al… Antoniou, AC*, and Chenevix-Trench, G.* (2015) Identification of six new susceptibility loci for invasive epithelial ovarian cancer.Nature genetics 47, 164-171. PMID 25581431 *Joint senior author
Kuchenbaecker, K., et al…. Antoniou AC, (2014) Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers.Breast Cancer Research 16, 3416.PMID 25919761
Ali HR, et al (2014) Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients. Ann. Oncol. 25, 1536-43. PMID 24915873.
Antoniou, A.C., et al… (2014) Breast-cancer risk in families with mutations in PALB2. N Engl J Med 371:497-506. PMID 25337756
Milne RL, et al …Easton DF (2014) A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium. Hum Mol Genet 23 (7): 1934-1946 PMID24242184
Lee AJ, et al … Antoniou AC (2013) BOADICEA breast cancer risk prediction model: updates to cancer incidences, tumour pathology and web interface.Br J Cancer 110(2):535-45. PMID 24346285
Couch FJ, et al … Antoniou AC (2013) Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk. PLOS Genetics (Mar;9(3):e1003212.) PubMed ID 23544013
Mavaddat N, et all…Easton DF (2013) Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE. J Natl Cancer Inst 105 (11): 812-822 PMID23628597
Michailidou K, et al …Easton DF (2013) Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet 45 : 353-361 PMID 23535729
Pharoah PD, et al (2013) GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat. Genet. 45, 362-70. PMID 23535730.
Barnes DR, et al … Antoniou AC (2012) Evaluation of Association Methods for Analysing Modifiers of Disease Risk in Carriers of High-Risk Mutations.Genet Epidemiol 36:274-91 PMID 22714938
Bolton KL, et al (2012) Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. J.A.M.A. 307, 382-90. PMID 22274685.
Ghoussaini M, et al … Easton DF (2012) Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet 44 : 312-318. PMID 22267197
Varghese JS, et al … Easton DF (2012) Mammographic breast density and breast cancer: evidence of a shared genetic basis. Cancer Res 72 : 1478-84. PMID22266113
Mulligan AM, et al … Antoniou AC (2011) Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.Br Cancer Res 13(6):R11 PubMed ID 22053997
Loveday C, et al … (2011) RAD51D is an ovarian cancer predisposition gene. Nat Genet 43:879-82 PubMed ID 21822267
Kote-Jarai Z, et al … (2011) Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet 43 : 785-791. PMID 21743467
Mcinnis RJ, et al … (2011) A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact.Genet Epidemiol 35:549-56 PMID 21769933
Antoniou AC, et al … (2010) Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction.Cancer Res 70:9742-54 PMID 21118973
Turnbull C, et al … (2010) Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 42:504-507. PMID20453838
Antoniou AC, et al … (2010) A locus on 19p13 locus modifies risk of breast cancer for BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.Nat Genet 42:174-91 PMID 20852631
Goode EL, et al (2010) A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat. Genet. 42, 874-9. PMID 20852632.
Mavaddat N, et al … (2010) Incorporating tumour pathology information into breast cancer risk prediction algorithms.Breast Cancer Res 18;12(3):R28. PMID 20482762
Blows FM, et al (2010) Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med 7, e1000279. PMID 20520800.
Ahmed S, et al … Easton DF (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 41:585-590. PubMed ID 19330027
Al Olama AA, et al … Easton DF (2009) Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat Genet 41 : 1058-1060 PMID 19767752
Eeles RA, et al … (2009) Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet 41 : 1116-1121 PubMed ID19767753
Song Het al (2009) A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat. Genet. 41, 996-1000. PubMed ID 19648919.
Eeles RA, et al … (2008) Identification of multiple novel prostate cancer susceptibility loci by a genome-wide association study. Nat Genet 40 : 316-321
Antoniou AC, et al … (2008) The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.Br J Cancer 98:1457-66. PubMed ID18349832
Pharoah PD, et al (2008) Polygenes, risk prediction, and targeted prevention of breast cancer. N. Engl. J. Med. 358, 2796-803. PMID 18579814.